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pentobarbital will minimize the level or effect of diltiazem by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
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pentobarbital improves toxicity of methoxyflurane by rising metabolism. Contraindicated. Elevated metabolism of methoxyflurane to nephrotoxic compounds.
pentobarbital decreases effects of hemin by pharmacodynamic antagonism. Use Caution/Observe. Drugs that improve delta-aminolevulinic acid synthetase may perhaps lessen hemin influence.
pentobarbital will lower the extent or result of lefamulin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Avoid coadministration of lefamulin with sturdy or moderate CYP3A inducers Except the reward outweighs hazards. Keep track of for minimized efficacy.
Barbiturates are substituted pyrimidine derivatives by which The essential construction popular to these drugs is barbituric acid, a compound that has no central nervous program (CNS) activity. CNS action is received by substituting alkyl, alkenyl, or aryl groups about the pyrimidine ring.
pentobarbital will minimize the level or influence of isradipine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unfamiliar.
Phenobarbital lowers the plasma levels of dicumarol (identify Earlier utilized: bishydroxycoumarin) and results in a lower in anticoagulant activity as calculated from the prothrombin time. Barbiturates can induce hepatic microsomal enzymes causing increased metabolism and lessened anticoagulant reaction of oral anticoagulants (e.
The barbiturates are nonselective central anxious system depressants which might be principally employed as sedative hypnotics and also anticonvulsants in subhypnotic doses.
pentobarbital will minimize the extent or impact of terbinafine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
pentobarbital will reduce the level or impact of duvelisib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration with a robust CYP3A inducer decreases duvelisib place beneath the curve (AUC), which can minimize duvelisib efficacy.
pentobarbital will lessen the extent or influence of conjugated estrogens by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
pentobarbital will decrease the extent or influence of cyclosporine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
Barbiturates may very check here well be habit forming. Tolerance and psychological and Bodily dependence may possibly manifest with continuing use.